Publications

Publications 2013

TMA CONSTRUCTION AND IMMUNOHISTOCHEMISTRY {additional file 1}


RNA EXTRACTION AND RT‐PCR METHODOLOGY {additional file 2}


DESCRIPTIVES OF PROTEIN AND mRNA EXPRESSION {Supplementary Table 1, additional file 3}


ASSOCIATIONS BETWEEN CLINICOPATHOLOGICAL VARIABLES AND NOTCH PATHWAY COMPONENTS AT THE mRNA AND PROTEIN LEVELS (pvalues) {Supplementary Table 2, additional file 4}


PROGNOSTIC SIGNIFICANCE OF CLINICOPATHOLOGICAL CHARACTERISTICS CHARACTERISTICS {Supplementary Table 3, additional file 5}


PROGNOSTIC SIGNIFICANCE OF mRNA PROTEIN EXPRESSION ON DISEASE-FREE SURVIVAL {Supplementary Table 4, additional file 6}


 

PROGNOSTIC SIGNIFICANCE OF RACGAP1 mRNA EXPRESSION IN HIGH-RISK EARLY BREAST CANCER: A STUDY IN PRIMARY TUMORS OF BREAST CANCER PATIENTS PARTICIPATING IN A RANDOMIZED HELLENIC COOPERATIVE ONCOLOGY GROUP TRIAL
K. Pliarchopoulou, K.T. Kalogeras, R. Kronenwett, R.M. Wirtz, A.G. Eleftheraki, A. Batistatou, M. Bobos, N. Soupos, G. Polychronidou, H. Gogas, E. Samantas, C. Christodoulou, T. Makatsoris, N. Pavlidis, D. Pectasides, G. Fountzilas
Cancer Chemother Pharmacol. 2013 Jan;71(1):245-55. doi: 10.1007/s00280-012-2002-z (Epub 2012 Oct 25)


A PHASE I STUDY OF TEMOZOLOMIDE AND LAPATINIB COMBINATION IN PATIENTS WITH RECURRENT HIGH-GRADE GLIOMAS
V. Karavasilis, V. Kotoula, G. Pentheroudakis, D.Televantou, S. Lambaki, S. Chrisafi,M. Bobos, G. Fountzilas
J Neurol. 2013 Jun;260(6):1469-80. doi: 10.1007/s00415-012-6812-z. (Epub 2013 Jan 5)


INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R) EXPRESSION AND SURVIVAL IN OPERABLE SQUAMOUS-CELL LARYNGEAL CANCER
G. Mountzios, I. Kostopoulos, V. Kotoula, I. Sfakianaki, E. Fountzilas, K. Markou, I. Karasmanis, S. Levva, N. Angouridakis, K. Vlachtsis, A. Nikolaou, J. Constantinidis, G. Fountzilas
PLoS One. 2013;8(1):e54048. doi: 10.1371/journal.pone.0054048 (Epub 2013 Jan 24)


EXPRESSION PROFILING OF 21 BIOMOLECULES IN LOCALLY ADVANCED NASOPHARYNGEAL CARCINOMAS OF CAUCASIAN PATIENTS
D. Krikelis, M. Bobos, G. Karayannopoulou, L. Resiga, S. Chrysafi, E. Samantas, D. Andreopoulos, V. Vassiliou, E. Ciuleanu, G. Fountzilas G
BMC Clin Pathol. 2013 Jan 29;13:1. doi: 10.1186/1472-6890-13-1


PSYCHIATRIC MANIFESTATIONS, PERSONALITY TRAITS AND HEALTH-RELATED QUALITY OF LIFE IN CANCER OF UNKNOWN PRIMARY SITE
T. Hyphantis, I. Papadimitriou, D. Petrakis, G. Fountzilas, D. Repana, K. Assimakopoulos, A.F. Carvalho, N. Pavlidis
Psychooncology. 2013 Jan 29. doi: 10.1002/pon.3244. (Epub ahead of print)


SAMPLE PARAMETERS AFFECTING THE CLINICAL RELEVANCE OF RNA BIOMARKERS IN TRANSLATIONAL BREAST CANCER RESEACH
V. Kotoula, K.T Kalogeras, G. Kouvatseas, D. Televantou, R. Kronenwett, R.M Wirtz, G. Fountzilas
Virchows Arch. 2013 Feb;462(2):141-54. doi: 10.1007/s00428-012-1357-1. (Epub 2012 Dec 20)


BIOMARKERS OF BENEFIT FROM CETUXIMAB-BASED THERAPY IN METASTATIC COLORECTAL CANCER: INTERACTION OF EGFR LIGAND EXPRESSION WITH RAS/RAF, PIK3CA GENOTYPES
G. Pentheroudakis, V. Kotoula, W. De Roock, G. Kouvatseas, P. Papakostas, T. Makatsoris, D. Papamichael, I. Xanthakis, J. Sgouros, D. Televantou, G. Kafiri, A.C. Tsamandas, E. Razis, E. Galani, D. Bafaloukos, I. Efstratiou, I. Bompolaki, D. Pectasides, N. Pavlidis, S. Tejpar, G. Fountzilas
BMC Cancer. 2013 Feb 2;13:49. doi: 10.1186/1471-2407-13-49


CYCLIN D1, EGFR, AND Akt/mTOR PATHWAY. POTENTIAL PROGNOSTIC MARKERS IN LOCALIZED LARYNGEAL SQUAMOUS CELL CARCINOMA
D. Dionysopoulos, K. Pavlakis, V. Kotoula, E. Fountzilas, K. Markou, I. Karasmanis, N. Angouridakis, A. Nikolaou, K.T Kalogeras, G. Fountzilas
Strahlenther Onkol. 2013 Mar;189(3):202-14. doi: 10.1007/s00066-012-0275-0 (Epub 2013 Feb 13)


HER2 GENE COPY NUMBER STATUS MAY INFLUENCE CLINICAL EFFICACY TO ANTI-EGFR MONOCLONAL ANTIBODIES IN METASTATIC COLORECTAL CANCER PATIENTS
V. Martin, L. Landi, F. Molinari, G. Fountzilas G, R. Geva, A. Riva, P. Saletti, S. De Dosso, A. Spitale, S. Tejpar, K.T Kalogeras, L. Mazzucchelli, M. Frattini, F. Cappuzzo
Br J Cancer. 2013 Feb 19;108(3):668-75. doi: 10.1038/bjc.2013.4 (Epub 2013 Jan 24)


DOSE SELECTION TRIAL OF METRONOMIC ORAL VINORELBINE MONOTHERAPY IN PATIENTS WITH METASTATIC CANCER: A HELLENIC COOPERATIVE ONCOLOGY GROUP CLINICALTRANSLATIONAL STUDY
E. Briasoulis, G. Aravantinos, G. Kouvatseas, P. Pappas, E. Biziota, I. Sainis, T. Makatsoris, I. Varthalitis, I. Xanthakis, A. Vassias, G. Klouvas, I. Boukovinas, G. Fountzilas, K.N Syrigos, H. Kalofonos, E. Samantas
BMC Cancer. 2013 May 29;13(1):263 (Epub ahead of print)


MOLECULAR PROFILE OF HEAD AND NECK SQUAMOUS CELL CARCINOMAS BEARING p16 HIGH PHENOTYPE
T. Rampias, E. Pectasides, M. Prasad, C. Sasaki, P. Gouveris, A. Dimou, P. Kountourakis, C. Perisanidis,
B. Burtness, T. Zaramboukas, D. Rimm, G. Fountzilas, A. Psyrri
Ann Oncol. 2013 Aug;24(8):2124-31. doi: 10.1093/annonc/mdt013 (Epub 2013 Feb 13)


EVALUATION OF THE PROGNOSTIC ROLE OF CENTROMERE 17 GAIN AND HER2/TOPOISOMERASE II ALPHA GENE STATUS AND PROTEIN EXPRESSION IN PATIENTS WITH BREAST CANCER TREATED WITH ANTHRACYCLINE-CONTAINING ADJUVANT CHEMOTHERAPY: POOLED ANALYSIS OF TWO HELLENIC COOPERATIVE ONCOLOGY GROUP (HeCOG) PHASE III TRIALS
G. Fountzilas, U. Dafni, M. Bobos, V. Kotoula, A. Batistatou, I. Xanthakis, C. Papadimitriou, I. Kostopoulos, T. Koletsa, E. Tsolaki, D. Televantou, E. Timotheadou, A. Koutras, G. Klouvas, E. Samantas, N. Pisanidis, C. Karanikiotis, I. Sfakianaki, N. Pavlidis, H. Gogas, H. Linardou, K.T Kalogeras KT, D. Pectasides, M.A Dimopoulos
BMC Cancer. 2013 Mar 28;13:163. doi: 10.1186/1471-2407-13-163


PREVALENCE OF BRCA1 MUTATIONS IN FAMILIAL AND SPORADIC GREEK OVARIAN CANCER CASES
A.V Stavropoulou, F. Fostira, M. Pertesi, M. Tsitlaidou, G.E Voutsinas, O. Triantafyllidou, A. Bamias, M.A Dimopoulos, E. Timotheadou, D. Pectasides, C. Christodoulou, G. Klouvas, C. Papadimitriou, T. Makatsoris, G. Pentheroudakis, G. Aravantinos, V. Karydakis, D. Yannoukakos, G. Fountzilas, I. Konstantopoulou
PLoS One. 2013;8(3):e58182. doi: 10.1371/journal.pone.0058182. (Epub 2013 Mar 11)


DARPP32, STAT5 AND STAT3 mRNA EXPRESSION RATIOS IN GLIOBLASTOMAS ARE ASSOCIATED WITH PATIENT OUTCOME
D. Televantou, G. Karkavelas, P. Hytiroglou, S. Lampaki, Iliadis G, Selviaridis P, Polyzoidis KS,
G. Fountzilas, V. Kotoula
Pathol Oncol Res. 2013 Apr;19(2):329-43. doi: 10.1007/s12253-012-9588-7 (Epub 2012 Dec 20)


GLOBAL microRNA PROFILING IN FAVORABLE PROGNOSIS SUBGROUPS OF CANCER OF UNKNOWN PRIMARY (CUP) DEMONSTRATES NO SIGNIFICANT EXPRESSION DIFFERENCES WITH METASTASES OF MATCHED KNOWN PRIMARY TUMORS
G. Pentheroudakis, Y. Spector, D. Krikelis, V. Kotoula, E. Meiri, V. Malamou-Mitsi, G. Fountzilas, M. Sanden, N. Pavlidis, H. Benjamin, R. Aharonov
Clin Exp Metastasis. 2013 Apr;30(4):431-9. doi: 10.1007/s10585-012-9548-3. (Epub 2012 Nov 4)


EVALUATION OF CURRENT PROGNOSTIC AND PREDICTIVE MARKERS IN BREAST CANCER: A VALIDATION STUDY OF TISSUE MICROARRAYS
A. Batistatou, D. Televantou, M. Bobos, A.G Eleftheraki, E. Kouvaras, S. Chrisafi, G.K Koukoulis, V. Malamou-Mitsi, G. Fountzilas
Anticancer Res. 2013 May;33(5):2139-45


IXABEPILONE ADMINISTERED WEEKLY OR EVERY THREE WEEKS IN HER2-NEGATIVE METASTATIC BREAST CANCER PATIENTS; A RANDOMIZED NON-COMPARATIVE PHASE II TRIAL
G. Fountzilas, V. Kotoula, D. Pectasides, G. Kouvatseas, E. Timotheadou, M. Bobos, X. Mavropoulou, C. Papadimitriou, E. Vrettou, G. Raptou, A. Koutras, E. Razis, D. Bafaloukos, E. Samantas, G. Pentheroudakis, D.V. Skarlos

PLoS One. 2013 Jul 23;8(7):e69256. doi: 10.1371/journal.pone.0069256. Print 2013


DEVELOPMENT AND VALIDATION OF A PROGNOSTIC MODEL IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA TREATED WITH SUNITINIB: A EUROPEAN COLLABORATION
A. Bamias, K. Tzannis, B. Beuselinck, S. Oudard, B. Escudier, D. Diosynopoulos, K. Papazisis, H. Lang, P. Wolter, E. de Guillebon, K. Stravodimos, M. Chrisofos, G. Fountzilas, R.T. Elaidi, M.A. Dimopoulos, C. Bamia

Br J Cancer. 2013 Jul 23;109(2):332-41. doi: 10.1038/bjc.2013.341. Epub 2013 Jun 27


PROGNOSTIC SIGNIFICANCE OF ESR1 GENE AMPLIFICATION, mRNA/PROTEIN EXPRESSION AND FUNCTIONAL PROFILES IN HIGH-RISK EARLY BREAST CANCER: A TRANSLATIONAL STUDY OF THE HELLENIC COOPERATIVE ONCOLOGY GROUP (HeCOG)
G. Pentheroudakis, V. Kotoula, A.G. Eleftheraki, E. Tsolaki, R.M. Wirtz, K.T. Kalogeras, A. Batistatou, M. Bobos, M.A. Dimopoulos, E. Timotheadou, H. Gogas, C. Christodoulou, K. Papadopoulou, I. Efstratiou, C.D Scopa, I. Papaspyrou, D. Vlachodimitropoulos, H. Linardou, E. Samantas, D. Pectasides, N. Pavlidis, G. Fountzilas

PLoS One. 2013 Jul 29;8(7):e70634. doi: 10.1371/journal.pone.0070634. Print 2013


THE PROGNOSTIC ROLE OF EPHRIN A2 AND ENDOTHELIAL GROWTH FACTOR RECEPTOR PATHWAY MEDIATORS IN PATIENTS WITH ADVANCED COLORECTAL CANCER TREATED WITH CETUXIMAB
A. Strimpakos, G. Pentheroudakis, V. Kotoula, W. De Roock, G. Kouvatseas, P. Papakostas,T. Makatsoris, D. Papamichael, A. Andreadou, J. Sgouros, A. Zizi-Sermpetzoglou, A. Kominea, D. Televantou, E. Razis, E. Galani, D. Pectasides, S. Tejpar, K. Syrigos, G. Fountzilas

Clin Colorectal Cancer. 2013 Dec;12(4):267-274.e2. doi: 10.1016/j.clcc.2013.07.001. (Epub 2013 Sep 17)


THE PROGNOSTIC SIGNIFICANCE OF WNT PATHWAY IN SURGICALLY-TREATED COLORECTAL CANCER: β-CATENIN EXPRESSION PREDICTS FOR DISEASE-FREE SURVIVAL
K. Kamposioras, A. Konstantara, V. Kotoula, S. Lakis, G. Kouvatseas, E. Akriviadis, E. Vrettou, D. Dionysopoulos, D. Krikelis, K. Papadopoulou, E. Charalambous, S. Chrisafi, C. Konstantaras, G. Fountzilas

Anticancer Res. 2013 Oct;33(10):4573-84


MULTIPLE INDEPENDENT VARIANTS AT THE TERT LOCUS ARE ASSOCIATED WITH TELOMERE LENGTH AND RISKS OF BREAST AND OVARIAN CANCER
S.E.Bojesen ... D. Yannoukakos ... G. Fountzilas et al

Nat Genet. 2013 Apr;45(4):371-84, 384e1-2. doi: 10.1038/ng.2566


VASCULAR ENDOTHELIAL GROWTH FACTOR POLYMORPHISMS AND CLINICAL OUTCOME IN PATIENTS WITH METASTATIC BREAST CANCER TREATED WITH WEEKLY DOCETAXEL
A.K. Koutras, V. Kotoula, C. Papadimitriou, D. Dionysopoulos, F. Zagouri, H.P. Kalofonos,H.P. Kourea, D.V. Skarlos, E. Samantas, K. Papadopoulou, P. Kosmidis, D. Pectasides, G. Fountzilas

Pharmacogenomics J. 2013 Sep 24. doi: 10.1038/tpj.2013.36. [Epub ahead of print]


HIGH PREVALENCE OF BRCA1 FOUNDER MUTATIONS IN GREEK BREAST/OVARIAN FAMILIES
I. Konstantopoulou, M. Tsitlaidou, F. Fostira, M. Pertesi, A.V Stavropoulou, O. Triantafyllidou, E. Tsotra, A. Tsiftsoglou, C. Tsionou, S. Droufakou, C. Dimitrakakis, G. Fountzilas, D. Yannoukakos
Clin Genet. 2013 Sep 6. doi: 10.1111/cge.12274. [Epub ahead of print]


IDENTIFICATION AND VALIDATION OF A MULTIGENE PREDICTOR OF RECURRENCE IN PRIMARY LARYNGEAL CANCER
E. Fountzilas, V. Kotoula, N. Angouridakis, I. Karasmanis, R.M. Wirtz, A.G. Eleftheraki, E. Veltrup, K. Markou, A. Nikolaou, D. Pectasides, G. Fountzilas
PLoS One. 2013 Aug 9;8(8):e70429. doi: 10.1371/journal.pone.0070429. (eCollection 2013)


NOVEL microRNA-BASED ASSAY DEMONSTRATES 92% AGREEMENT WITH DIAGNOSIS BASED ON CLINICOPATHOLOGIC AND MANAGEMENT DATA IN A COHORT OF PATIENTS WITH CARCINOMA OF UNKNOWN PRIMARY
G. Pentheroudakis, N. Pavlidis, G. Fountzilas, D. Krikelis, A. Goussia, A. Stoyianni, M. Sanden, B. St Cyr, N. Yerushalmi, H. Benjamin, E. Meiri, A. Chajut, S. Rosenwald, R. Aharonov, Y. Spector
Mol Cancer. 2013 Jun 10;12:57. doi: 10.1186/1476-4598-12-57


BEVACIZUMAB AND MICROMETASTASES: REVISITING THE PRECLINICAL AND CLINICAL ROLLERCOASTER
G. Mountzios, G. Pentheroudakis, P. Carmeliet
Pharmacol Ther. 2013 Sep 27. pii: S0163-7258(13)00192-7. doi: 10.1016/j.pharmthera.2013.09.003. [Epubahead of print]


INSIGHTS INTO THE EPITHELIAL MESENCHYMAL TRANSITION PHENOTYPE IN CANCER OF UNKNOWN PRIMARY FROM A GLOBAL MICRORNA PROFILING STUDY", HAS BEEN ACCEPTED FOR PUBLICATION IN CLINICAL AND TRANSLATIONAL ONCOLOGY
A. Stoyianni, G. Pentheroudakis, H. Benjamin, A. Cervantes, K. Ashkenazi, G. Lazaridis, N. Pavlidis, Y Spector
Clin Transl Oncol. 2013 Nov 27. [Epub ahead of print]


EXPLORING THE BIOLOGY OF CANCER OF UNKNOWN PRIMARY: BREAKTHROUGHS AND DRAWBACKS
K. Kamposioras, G. Pentheroudakis, N. Pavlidis
Eur J Clin Invest 2013 May;43(5):491-500. doi: 10.1111/eci.12062. Epub 2013 Mar 11. Review